GENEBRITE IN VIVO GENE EXPRESSION MODELS

WHOLE-BODY IMAGING OF ADENOVIRUS-GFP EXPRESSION

Whole-body image of vAd-GFP gene expression in the liver

Whole-body image of vAd-GFP gene expression in the liver

Whole-body image of vAd-GFP gene expression in the brain

An external image of vAd-GFP gene expression accquired from a nude mouse in the light box 72 hours after tail vein injection. 
An external image of vAd-GFP gene expression accquired from a nude mouse in the light box 72 hours after portal vein injection. 

An external image of vAd-GFP gene expression in the brain acquired from a nude mouse in a light box 24 hours after after gene delivery. 

Yang, M., Baranov, E., Moossa, A.R., Penman, S., Hoffman, R.M.  Visualizing gene expression by whole-body fluorescence imaging.  Proc. Natl. Acad. Sci. USA 97, 12278-12282, 2000.

COMPARISON OF WHOLE-BODY AND INTRA-VITAL IMAGES OF ADENOVIRUS-GFP EXPRESSION IN VARIOUS ORGANS OF NUDE MICE

Whole-body imaging        Intra-vital imaging

Yang, M., Baranov, E., Moossa, A.R., Penman, S., Hoffman, R.M.  Visualizing gene expression by whole-body fluorescence imaging.  Proc. Natl. Acad. Sci. USA 97, 12278-12282, 2000.

INTRA-VITAL IMAGING OF LENTIVIRUS-GFP EXPRESSION

Lentivirus-GFP expression in the liver of nude mouse

Pfeifer, A., Kessler, T., Yang, M., Baranov, E., Kootstra, N., Cheresh, D.A., Hoffman, R.M., and Verma, I.M.  Transduction of liver cells by lentiviral vectors: Analysis in living animals.  Molecular Therapy 3, 319-322, 2001.