Patient Tumorgraft-to-PDOX (Patient Derived Orthotopic Xenograft) Publications

        1. Fu, X., Besterman, J.M., Monosov, A., and Hoffman, R.M. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc. Natl. Acad. Sci. USA 88, 9345-9349, 1991.

2. Fu, X., Guadagni, F., and Hoffman, R.M. A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically from histologically intact patient specimens. Proc. Natl. Acad. Sci. USA 89, 5645-5649, 1992.

3. Fu, X., and Hoffman, R.M. Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens. Anticancer Research 13, 283-286, 1993.

4. Fu, X., Le, P. and Hoffman, R.M. A metastatic-orthotopic transplant nude‑mouse model of human patient breast cancer. Anticancer Res. 13, 901‑904, 1993.

5. Riordan, T. A technique is said to ease attachment of tumors to mice, making them ‘little cancer patients.’ New York Times, “Patents” Column, March 4, 1996.

6. Holzman, D. Of mice and metastasis: A new for-profit model emerges. Journal of the National Cancer Institute 88, 396-397, 1996.

7. Hoffman, R.M. Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Investigational New Drugs 17, 343-359, 1999.

8. Garber, K. Realistic rodents? Debate grows over new mouse models of cancer. Journal of the National Cancer Institute 98, 1176-1178, 2006.

9. Kaushal, S., McElroy, M.K., Luiken, G.A., Talamini, M.A., Moossa, A.R., Hoffman, R.M., and Bouvet, M. Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J. Gastrointest. Surg. 12, 1938-1950, 2008.

          

     10. Suetsugu, A., Katz, M., Fleming, J., Moriwaki, H., Bouvet, M., Saji, S., and Hoffman, R.M. Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens. J. Cell. Biochem. 113, 2290-2295, 2012.

11. Suetsugu, A., Katz, M., Fleming, J., Truty, M., Thomas, R., Saji, S., Moriwaki, H., Bouvet, M., and Hoffman, R.M. Imageable fluorescent metastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens. Anticancer Research 32, 1175-1180, 2012.

12. Suetsugu, A., Katz, M., Fleming, J., Truty, M., Thomas, R., Saji, S., Moriwaki, H., Bouvet, M., and Hoffman, R.M. Non-invasive fluorescent-protein imaging of orthotopic pancreatic-cancer-patient tumorgraft progression in nude mice. Anticancer Research 32, 3063-3068, 2012.