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For
Release at 6:00am EST May 14, 2004
NEWS
– NEWS – NEWS
Genetic profile of AntiCancer’s
mouse model of prostate cancer predicts recurrence in human prostate cancer
patients
A recent article in the Journal of Clinical Investigation by
Gennadi Glinsky, et al., describes how scientists from AntiCancer Inc. and the Sidney Kimmel Cancer
Center, have used AntiCancer’s MetaMouse® model of metastatic human
prostate cancer to determine genetic signatures which predict whether patients
would have recurrence of prostate cancer.
Existing procedures for prediction of recurrence of prostate
cancer, including blood tests such as the prostate specific antigen (PSA) test and
other standard pathological examinations that have been used for decades, have
limited prognostic capability. AntiCancer’s clinically-relevant MetaMouse®
model of prostate cancer, used in the present study, in combination with modern
methods of gene profiling have enabled the development of a more discriminating
test for predicting prostate cancer recurrence. This new test will be further
evaluated in order to make it available on a broad basis.
This study is a significant advance in our ability to more
accurately predict the clinical outcome of prostate cancer patients. This test
will be useful in determining more effective treatment for the disease. The success of the current study demonstrates
the clinical relevance of AntiCancer’s MetaMouse® models. AntiCancer has similar patient-like MetaMouse®
models for all major types of human cancer that are used for the discovery of
new drugs and genes for the cure and diagnosis of cancer.
AntiCancer,
founded in 1984 and based in San Diego, is also developing new drugs for cancer
based on genetic engineering, targeting cancer-specific metabolic defects. The company is also developing other diagnostics
for cancer and other diseases as well as gene and stem-cell therapy of cancer,
hair growth and other diseases.
For more information, see
AntiCancer’s website at www.anticancer.com
or contact Charlene M. Cooper, E-mail: all@anticancer.com.