MetaMouse® Publications:

General

  1. Dutton, G.  AntiCancer Inc. scientists identify a key governing step in the metastasis of cancer.  Genetic Engineering News 16, 1, January 15, 1996. [PDF]

  2. Holzman, D.  Of mice and metastasis: A new for-profit model emerges.  Journal of the National Cancer Institute 88, 396-397, 1996.[PDF] 

  3. Riordan, T.  A technique is said to ease attachment of tumors to mice, making them ‘little cancer patients.’  New York Times, “Patents” Column, March 4, 1996. [PDF]

  4. Dove, A.  Illuminating cancer models.  Nature Biotechnology 18, 261, 2000. [PDF]

  5. McCann, J.  Jellyfish protein gives new glow to tumor imaging.  Journal of the National Cancer Institute 93, 976-977, 2001[PDF].  

Bladder

  1. Fu, X., Theodorescu, D., Kerbel, R.S., and Hoffman, R.M.  Extensive multi-organ metastasis following orthotopic onplantation of histologically-intact human bladder carcinoma tissue in nude mice.  Int. J. Cancer 49, 938-939, 1991.[PDF] 

  2. Fu, X., and Hoffman, R.M.  Human RT-4 bladder carcinoma is highly metastatic in nude mice and comparable to ras-H-transformed RT-4 when orthotopically onplanted as histologically intact tissue.  Int. J. Cancer 51, 989-991, 1992.[PDF]   

  3. Chang, S-G., Kim, J.I., Jung, J-C., Rho, Y-S., Lee, K-T., An, Z., Wang, X., and Hoffman, R.M.  Antimetastatic activity of the new platinum analog {Pt(cis-dach)(DPPE)×2NO3} in a metastatic model of human bladder cancer.  Anticancer Res. 17, 3239-3242, 1997.[PDF] 

  4. Zhou, J-H., Rosser, C.J., Tanaka, M., Yang, M., Baranov, E., Hoffman, R.M., Benedict, W.F. Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression.  Cancer Gene Therapy 9, 681-686, 2002. [PDF]

Breast

  1. Fu, X., Le, P., and Hoffman, R.M.  A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.  Anticancer Res. 13, 901-904, 1993. [PDF]

  2. Kubota, T., Inoue, S., Furukawa, T., Ishibiki, K., Kitajima, M., Kawamura, E., and Hoffman, R.M.  Similarity of serum – Tumor pharmacokinetics of antitumor agents in man and nude mice.  Anticancer Res. 13, 1481-1484, 1993.[PDF]

  3.  Li, X-M., Wang, J-W., An, Z., Yang, M. Baranov, E., Jiang, P., Sun, F-X., Moossa, A.R., and Hoffman, R.M. Optically imageable metastatic model of human breast cancer. Clinical & Experimental Metastasis, 19, 347-350, 2002. [PDF]

  4. John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I., Jarvis, G.A. Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer. Clinical Cancer Res. 9, 3808-3814, 2003 [PDF]

  5. Goodison, S., Kawai, K., Hihara, J., Jiang, P., Yang, M., Urquidi, V., Hoffman, R.M., and Tarin, D. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from non-metastatic breast tumors revealed by labeling with green fluorescent protein. Clinical Cancer Res. 9, 3808-3814, 2003. [PDF] 

  6. Tsuji, K., Yamauchi, K., Yang, M., Jiang, P., Bouvet, M., Endo, H., Kanai, Y., Yamashita, K., Moosa, A.R., and Hoffman, R.M. Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in portal vein area. Cancer Res. 66, 303-306, 2006.[PDF]

Colon

  1. Fu, X., Besterman, J.M., Monosov, A., and Hoffman, R.M.  Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens.  Proc. Natl. Acad. Sci. USA 88, 9345-9349, 1991.[PDF]

  2. Fu, X., Herrera, H., Kubota, T., and Hoffman, R.M.  Extensive liver metastasis from human colon cancer in nude and SCID mice after orthotopic onplantation of histologically-intact human colon carcinoma tissue.  Anticancer Res. 12, 1395-1398, 1992.[PDF] 

  3. Furukawa, T., Kubota, T., Watanabe, M., Kuo, T.H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M.  Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice.  Anticancer Res. 13, 287-291, 1993. [PDF] 

  4. Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M.  Early resection of primary orthotopically-growing human colon tumor in nude mouse prevents liver metastasis: further evidence for patient-like hematogenous metastatic route.  Anticancer Res. 13, 293-297, 1993. [PDF]

  5. Furukawa, T., Kubota, T., Watanabe, M., Kuo, T-H., Nishibori, H., Kase, S., Saikawa, Y., Tanino, H., Teramoto, T., Ishibiki, K., and Kitajima, M.  A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice.  Jpn. J. Surg. 23, 420-423, 1993. [PDF].

  6. Wang, X., Fu, X., Brown, P.D., Crimmin, M.J., and Hoffman, R.M.  Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.  Cancer Res. 54, 4726-4728, 1994.. [PDF] 

  7. Togo, S., Shimada, H., Kubota, T., Moossa, A.R., Hoffman, R.M.  “Seed” to “soil” is a return trip in metastasis. Anticancer Res. 15, 791-794, 1995.[PDF]

  8. Togo, S., Shimada, H., Kubota, T., Moossa, A.R., Hoffman, R.M.  Host organ specifically determines cancer progression.  Cancer Res. 55, 681-684, 1995.[PDF] 

  9. Kuo, T-H., Kubota, T., Watanbe, M., Furukawa, T., Teramoto, T., Ishibiki, K., Kitajimi, M., Moossa, A.R., Penman, S., Hoffman, R.M.  Liver colonization competence governs colon cancer metastasis.  Proc. Natl. Acad. Sci. USA 92, 12085-12089, 1995.[PDF]

  10. Togo, S., Wang, X., Shimada, H., Moossa, A.R., and Hoffman, R.M.  Cancer seed and soil can be highly selective: Human-patient colon tumor lung metastasis grows in nude mouse lung but not colon or subcutis.  Anticancer Res. 15, 795-798, 1995.[PDF]

  11. Leff, D.N.  MetaMouse models colon cancer metastasis with clinical potential.  BioWorld Today 7, 1, January 8, 1996. [PDF] 

  12. Murray, G., Duncan, M., O’Neil, P., Melvin, W., Fothergill, J.  Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer.  Nature Medicine 2, 461-462, 1996. [PDF]

  13. An, Z., Wang, X., Willmott, N., Chander, S.K., Tickle, S., Docherty, A.J., Mountain, A., Millican, A.T., Morphy, R., Porter, J.R., Epemolu, R.O., Kubota, T., Moossa, A.R., and Hoffman, R.M.  Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor.  Clinical & Experimental Metastasis 15, 184-195, 1997. [PDF]

  14. Sun, F-X., Sasson, A.R., Jiang, P., An, Z., Gamagami, R., Li, L., Moossa, A.R., and Hoffman, R.M.  An ultra-metastatic model of human colon cancer in nude mice. Clinical & Experimental Metastasis 17, 41-48, 1999. [PDF]

  15. Sasson, A.R., Gamagami, R., An, Z., Wang, X., Moossa, A.R., and Hoffman, R.M.  Cimetidine: An inhibitor or promoter of tumor growth?  International Journal of Cancer 81, 835-838, 1999. [PDF]

  16. Rho, Y-S., Lee, K-T., Jung, J-C., Yoon, C., An, Z., Hoffman, R.M., and Chang, S-G.  Efficacy of new platinum analog DPPE in an orthotopic nude mouse model of human colon cancer.  Anticancer Res. 19, 157-162, 1999. [PDF]

  17. Rashidi, B., An, Z., Sun, F-X., Sasson, A., Gamagammi, R., Moossa, A.R., Hoffman, R.M.  Minimal liver resection strongly stimulates the growth of human colon cancer in the liver of nude mice.  Clinical & Experimental Metastasis 17, 497-500, 1999. [PDF]

  18. Rashidi, B., Sun, F-X., Jiang, P., An, Z., Gamagami, R., Moossa, A.R., and Hoffman, R.M.  A nude mouse model of massive liver and lymph node metastasis of human colon cancer. Anticancer Res. 20, 715-722, 2000. [PDF] 

  19. Rashidi, B., An, Z., Sun, F-X., Moossa, A.R., and Hoffman, R.M.  Antimetastatic intraoperative chemotherapy of human colon tumors in the livers of nude mice.  Clinical Cancer Res. 6, 2464-2468, 2000.[PDF] 

  20. Rashidi, B., Gamagami, R., Sasson, A., Sun, F-X., Geller, J., Moossa, A.R., and Hoffman, R.M.  An orthotopic mouse model of remetastasis of human colon cancer liver metastasis.  Clinical Cancer Res. 6, 2556-2561, 2000. [PDF] 

  21. Tsuji, K., Yamauchi, K., Yang, M., Jiang, P., Bouvet, M., Endo, H., Kanai, Y., Yamashita, K., Moosa, A.R., and Hoffman, R.M. Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in portal vein area. Cancer Res. 66, 303-306, 2006.[PDF]

Gene Therapy

  1. Miki, K., Xu, M., An, Z., Wang, X., Yang, M., Al-Refaie, W., Sun, X., Baranov, E., Tan, Y., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M.  Survival efficacy of the combination of the methioninase gene and methioninase in a lung cancer orthotopic model.  Cancer Gene Therapy 7, 332-338, 2000. . [PDF]

  2. Miki, K., Al-Refaie, W., Xu, M., Jiang, P., Tan, Y., Bouvet, M., Zhao, M., Gupta, A., Chishima, T., Shimada, H., Makuuchi, M., Moossa, A.R., and Hoffman, R.M.  Methioninase gene therapy of human cancer cells is synergistic with recombinant methioninase treatment.  Cancer Res. 60, 2696-2702, 2000.[PDF]

  3. Hasegawa, S., Yang, M., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M.  In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis. Cancer Gene Therapy 7, 1336-1340, 2000. [PDF]

  4. Djeha, A.H., Thomson, T.A., Leung, H., Searle, P.F., Young, L.S., Kerr, D.J., Harris, P.A., Mountain, A., and Wrighton, C.J.  Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: A well-tolerated therapy for established solid tumors.  Molecular Therapy 3, 233-240, 2001. [PDF] 

  5. Chen, C.T., Lin, J., Li, Q., Phipps, S.S., Jakubczak, J.L., Stewart, D.A., Skripchenko, Y., Forry-Schaudies, S., Wood, J., Schnell, C., and Hallenbeck, P.L.  Antiangiogenic gene therapy for cancer via systemic administration of adenoviral vectors expressing secretable endostatin.  Human Gene Therapy 11, 1983-1996, 2000. [PDF]

  6. Miki, K, Xu, M., Gupta, A., Ba, Y., Tan, Y., Al-Refaie, W., Bouvet, M., Makuuchi, M., Moossa, A.R., and Hoffman, R.M.  Methioninase cancer gene therapy with selenomethionine as suicide prodrug substrate.  Cancer Research 61, 6805-6810, 2001. [PDF] 

  7. Kamiyama, M., Ichikawa, Y., Ishikawa, T., Chishima, T., Hasegawa, S., Hamaguchi, Y., Nagashima, Y., Miyagi, Y., Mitsuhashi, M., Hyndman, D., Hoffman, R.M., Ohki, S., and Shimada, H.  VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice. Cancer Gene Therapy 9, 197-201, 2002. [PDF]

  8. Pirocanac, E.C., Nassirpour, R., Yang, M., Wang, J-W., Nardin, S.R., Gu, J., Fang, B., Moossa, A.R., Hoffman, R.M., and Bouvet, M.  Bax-induction gene therapy of pancreatic cancer.  J. Surg. Res. 106, 346-351, 2002. [PDF]

  9. Hoffman, R.M. Immune reactions in skin and hair follicle gene therapy. Molecular Therapy 7, 294-295, 2003.

  10. Katz, M.H., Spivak, D.E., Takimoto, S., Fang, B., Burton, D.W., Moosa, A.R., Hoffman, R.M., Bouvet, M. Gene Therapy of Pancreatic Cancer With Green Fluorescent Protein and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Fusion Gene Expression Driven by a Human Telomerase Reverse Transcriptase Promoter. Annals of Surgical Oncology, 10(7): 762-772, 2003. [PDF] 

GFP

  1. Chishima, T., Miyagi, Y., Wang, X., Yamaoka, H., Shimada, H., Moossa, A.R., and Hoffman, R.M.  Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression.  Cancer Res. 57, 2042-2047, 1997. [PDF]

  2. Chishima, T., Miyagi, Y., Wang, X., Baranov, E., Tan, Y., Shimada, H., Moossa, A.R., and Hoffman, R.M.  Metastatic patterns of lung cancer visualized live and in process by green fluorescent protein expression.  Clinical & Experimental Metastasis 15, 547-552, 1997.[PDF]

  3. Chishima, T., Miyagi, Y., Wang, X., Tan, Y., Shimada, H., Moossa, A.R., and Hoffman, R.M.  Visualization of the metastatic process by green fluorescent protein expression.  Anticancer Res. 17, 2377-2384, 1997. [PDF]

  4. Chishima, T., Yang, M., Miyagi, Y., Li, L., Tan, Y., Baranov, E., Shimada, H., Moossa, A.R., Penman, S., and Hoffman, R.M.  Governing step of metastasis visualized in vitro.  Proc. Natl. Acad. Sci. USA 94, 11573-11576, 1997. [PDF]

  5. Chishima, T., Miyagi, Y., Li, L., Tan, Y., Baranov, E., Yang, M., Shimada, H., Moossa, A.R., and Hoffman, R.M.  The use of histoculture and green fluorescent protein to visualize tumor cell host interaction.  In Vitro Cell. Dev. Biol. 33, 745-747, 1997. [PDF]

  6. Yang, M., Hasegawa, S., Jiang, P., Wang, X., Tan, Y., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M.  Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression.  Cancer Res. 58, 4217-4221, 1998. [PDF]

  7. Yang, M., Jiang, P., Sun, F.X., Hasegawa, S., Baranov, E., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M.  A fluorescent orthotopic bone metastasis model of human prostate cancer. Cancer Res. 59, 781-786, 1999.[PDF] 

  8. Hoffman, R.M.  Orthotopic transplant mouse models with green fluorescent protein-expressing cancer cells to visualize metastasis and angiogenesis.  Cancer and Metastasis Reviews 17, 271-277, 1999. [PDF] 

  9. Hoffman, R.M.  Green fluorescent protein to visualize cancer progression and metastasis.  Methods in Enzymology, Green Fluorescent Protein, Vol. 302. Ed: P. Michael Conn, Academic Press, San Diego, pp. 20-31, 1999. [PDF]

  10. Naumov, G.N., Wilson, S.M., MacDonald, I.C., Schmidt, E.E., Morris, V.L., Groom, A.C., Hoffman, R.M., and Chambers, A.F.  Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis.  Journal of Cell Science 112, 1835-1842, 1999.

  11. Yang, M., Chishima, T., Baranov, E., Shimada, H., Moossa, A.R., and Hoffman, R.M.  Green fluorescent protein: A new light to visualize metastasis and angiogenesis in cancer.  Proc. of SPIE Conference on Molecular Imaging: Reporters, Dyes, Markers and Instrumentation 3500, 117-124, 1999.

  12. Yang, M., Jiang, P., An, Z., Baranov, E., Li, L., Hasegawa, S., Al-Tuwaijri, M., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M.  Genetically fluorescent melanoma bone and organ metastasis models.  Clinical Cancer Res. 5, 3549-3559, 1999. [PDF] 

  13. Yang, M., Chishima, T., Wang, X., Baranov, E., Shimada, H., Moossa, A.R., and Hoffman, R.M. Multi-organ metastatic capability of Chinese hamster ovary cells revealed by green fluorescent protein (GFP) expression.  Clinical & Experimental Metastasis, 17, 417-422, 1999.

  14. Hoffman, R.M.  Visualization of metastasis in orthotopic mouse models with green fluorescent protein. In: Relevance of Tumor Models in Anticancer Drugs Development.  Eds.: Fiebig, H.H., Burger, A.M., Kluwver Academic Publishers, Dordrecht, The Netherlands, Vol. 54, 81-87, 1999.

  15. Yang, M., Baranov, E., Jiang, P., Sun, F-X., Li, X-M., Li, L., Hasegawa, S., Bouvet, M., Al-Tuwaijri, M., Chishima, T., Shimada, H., Moossa, A.R., Penman, S., Hoffman, R.M. Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases.  Proc. Natl. Acad. Sci. USA 97, 1206-1211, 2000. [PDF] 

  16. Dove, A. Illuminating cancer models.  Nature Biotechnology 18, 261, 2000.

  17. Hoffman, R.M.  Correspondence re: Initial stages of tumor cell-induced angiogenesis: Evaluation via skin window chambers in rodent models. Journal of the National Cancer Institute 92, 1445, 2000.

  18. Yang, M., Baranov, E., Shimada, H., Moossa, A.R., and Hoffman, R.M.  External optical imaging freely-moving mice with green fluorescent protein-expressing metastatic tumors.  Proc. of SPIE Conference, 3921, 256-259, 2000.

  19. Corrigendum, BioFeedback.  Biotechniques 29, 544, September 2000.

  20. Yang, M., Baranov, E., Moossa, A.R., Penman, S., Hoffman, R.M.  Visualizing gene expression by whole-body fluorescence imaging.  Proc. Natl. Acad. Sci. USA 97, 12278-12282, 2000.[PDF]                           

  21. Hasegawa, S., Yang, M., Chishima, T., Shimada, H., Moossa, A.R., Hoffman, R.M.  In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis. Cancer Gene Therapy 7, 1336-1340, 2000. [PDF] 

  22. Rashidi, B., Yang, M., Jiang, P., Baranov, E., An, Z., Wang, X., Moossa, A.R., and Hoffman, R.M.  A highly metastatic Lewis lung carcinoma orthotopic green fluorescent protein model.  Clinical & Experimental Metastasis 18, 57-60, 2000. [PDF] 

  23. Bouvet, M., Yang, M., Nardin, S., Wang, X., Jiang, P., Baranov, E., Moossa, A.R., Hoffman, R.M.  Chronologically-specific metastatic targeting of human pancreatic tumors in orthotopic models.  Clinical & Experimental Metastasis 18, 213-218, 2000.

  24. Yang, M., Baranov, E., Li, X-M., Wang, J-W., Jiang, P., Li, L., Moossa, A.R., Penman, S., Hoffman, R.M.  Whole‑body and intravital optical imaging of angiogenesis in orthotopically implanted tumors.  Proc. Natl. Acad. Sci. USA 98, 2616-2621, 2001. [PDF]

  25. Robinson, K.  Imaging system captures whole-body GFP images.  Biophotonics International, April, 54-55, 2001.

  26. Pfeifer, A., Kessler, T., Yang, M., Baranov, E., Kootstra, N., Cheresh, D.A., Hoffman, R.M., and Verma, I.M.  Transduction of liver cells by lentiviral vectors: Analysis in living animals.  Molecular Therapy 3, 319-322, 2001.[PDF] 

  27. Hoffman, Robert M.  Visualization of GFP-expressing tumors and metastasis in vivo.  BioTechniques 30, 1016-1016, 2001.

  28. Hutchinson, E.  Fluorescence imaging of tumour metastasis and angiogenesis.  The Lancet Oncology, 2, 254, 2001.

  29. McCann, J.  Jellyfish protein gives new glow to tumor imaging.  Journal of the National Cancer Institute 93, 976-977, 2001.

  30. Lee, N.C., Bouvet, M., Nardin, S., Jiang, P., Baranov, E., Rashidi, B., Yang, M., Wang, X., Moossa, A.R., and Hoffman, R.M.  Antimetastatic efficacy of adjuvant gemcitabine in a pancreatic cancer orthotopic model.  Clinical & Experimental Metastasis 18, 379-384, 2001.[PDF] 

  31. Zhao, M., Yang.M., Baranov, E., Wang, X., Penman, S., Moossa, A.R., Hoffman, R.M. Spatial-temporal imaging of bacterial infection and antibiotic response in intact animals. Proc. Natl. Acad. Sci. USA 98, 9814-9818, 2001.[PDF] 

  32. Hoffman, R.M.   Green Fluorescent Protein for Metastasis Research.  In: Brooks, S., and Schumacher, U., eds. Metastasis Research Protocols. Vol. II. Analysis of Cell Behavior In Vitro and In Vivo.  Totowa, NJ: Humana Press Inc., 285-298, 2001.  

  33. Hoffman, R.M.  GFP-Expressing Metastatic-Cancer Mouse Models.  In:  Teicher, B., ed.  Tumor Models in Cancer Research.  Totowa, NJ: Humana Press Inc., 99-112, 2002.

  34. Kamiyama, M., Ichikawa, Y., Ishikawa, T., Chishima, T., Hasegawa, S., Hamaguchi, Y., Nagashima, Y., Miyagi, Y., Mitsuhashi, M., Hyndman, D., Hoffman, R.M., Ohki, S., and Shimada, H.  VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice. Cancer Gene Therapy 9, 197-201, 2002.

  35. Yang, M., Baranov, E., Wang, J-W., Jiang, P., Wang, X., Sun, F-X., Bouvet, M., Moossa, A.R., Penman, S., and Hoffman, R.M.  Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model.  Proc. Natl. Acad. Sci. USA 99, 3824-3829, 2002. [PDF] 

  36. Bouvet, M., Wang, J-W., Nardin, S.R., Nassirpour, R., Yang, M., Baranov, E., Jiang, P., Moossa, A.R., and Hoffman, R.M.  Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model.  Cancer Research 62, 1534-1540, 2002. [PDF]

  37. Hoffman, R.M.  Green fluorescent protein imaging of tumor cells in mice.  Lab Animal 31, 34-41, 2002.

  38. Bouvet, M., Nardin, S.R., Burton, D.W., Lee, N.C., Yang, M., Wang, X., Baranov, E., Behling, C., Moossa, A.R., Hoffman, R.M., and Deftos L.J.  Parathyroid hormone-related protein as a novel tumor marker in pancreatic adenocarcinoma.  Pancreas 24, 284-290, 2002.

  39. Schmitt, C.A., Fridman, J.S., Yang, M., Baranov, E., Hoffman, R.M. and Lowe, S.W.  Dissecting p53 tumor suppressor functions in vivo.  Cancer Cell 1, 289-298, 2002.[PDF]

  40. Schmitt, C.A., Yang, M., Fridman, J.S., Baranov, E., Hoffman, R.M., and Lowe, S.W.  Senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.  Cell 109, 335–346, 2002. [PDF] 

  41. Li, X-M., Wang, J-W., An, Z., Yang, M. Baranov, E., Jiang, P., Sun, F-X., Moossa, A.R., and Hoffman, R.M. Optically imageable metastatic model of human breast cancer. Clinical & Experimental Metastasis, 19, 347-350, 2002. [PDF] 

  42. Hoffman, R.M.  Watching real-time metastasis in vivo.  Trends in Molecular Medicine, 8(7), 354-355, 2002.

  43. Hoffman, R.M.  Whole-body fluorescence imaging with Green Fluorescence Protein.  In: Hicks, B.W., ed.  Methods in Molecular Biology, Vol. 183: Green Fluorescent Protein: Applications and Protocols.  Totowa, NJ: Humana Press, 135-148, 2002.

  44. Hoffman, R.M.  In vivo imaging of metastatic cancer with fluorescent proteins.  Journal of Cell Death and Differentiation 9, 786-789, 2002. [PDF] 

  45. Zhou, J-H., Rosser, C.J., Tanaka, M., Yang, M., Baranov, E., Hoffman, R.M., Benedict, W.F. Visualizing superficial human bladder cancer cell growth in vivo by green fluorescent protein expression.  Cancer Gene Therapy 9, 681-686, 2002.

  46. Hoffman, R.M.  Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models.  Lancet Oncology 3, 546-556, 2002. [PDF] 

  47. Saito, N., Zhao, M., Li, L., Baranov, E., Yang, M., Ohta, Y., Katsuoka, K., Penman, S., and Hoffman, R.M. High efficiency genetic modification of hair follicles and growing hair shafts. Proc. Natl. Acad. Sci USA  99, 13120-13124, 2002.

  48. Sun, F-X., Tohgo, A., Bouvet, M., Yagi, S., Nassirpour, R., Moossa, A.R., and Hoffman, R.M.  Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model.  Cancer Research 63, 80-85, 2003.[PDF] 

  49. Wang, J-W., Yang, M., Wang, X., Sun, F-X., Li, X-M., Yagi, S., and Hoffman, R.M. Antimetastatic efficacy of oral 5-FU imaged by green fluorescent protein in real time.  Anticancer Research 23, 1-6, 2003. [PDF]

  50. Yamamoto, N., Yang, M., Jiang, P., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M.  Real-time GFP imaging of spontaneous HT-1080 fibrosarcoma lung metastases.  Clin. Exp. Metastasis 20, 181-185, 2003.[PDF] 

  51. John, C.M., Leffler, H., Kahl-Knutsson, B., Svensson, I., Jarvis, G.A. Truncated Galectin-3 Inhibits Tumor Growth and Metastasis in Orthotopic Nude Mouse Model of Human Breast Cancer. Clinical Cancer Res. 9, 3808-3814, 2003 [PDF].

  52. Glinskii, A.B., Smith, B.A., Jiang, P., Li, X-M., Yang, M., Hoffman, R.M., Glinsky, G.V. Viable circulating metastatic cells produced in orthotopic but not ectopic prostate cancer models. Cancer Res. 63, 4239-4243, 2003.[PDF]

  53. Katz, M.H., Spivack, D.E., Takimoto, S., Fang, B., Burton, D.W., Moosa, A.R., Hoffman, R.M., and Bouvet, M. Gene therapy of pancreatic cancer with green fluorescent protein and tumor necrosis factor-related apoptosis-inducing ligand fusion gene expression driven by a human telomerase reverse transcriptase promoter. Annals of Surgical Oncology 10, 762-772, 2203.

  54. Katz, M., Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M., Bouvet, M. A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical  evaluation of chemotherapeutics. J.Surg. Res. 113, 151-160, 2003.[PDF] 

  55. Katz, M.H., Bouvet, M., Takimoto, S., Spivac, D., Moossa, A.R., Hoffman, R.M. Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. Cancer Res. 63, 5521-5525, 2003.[PDF] 

  56. Goodison, S., Kawai, K., Hihara, J., Jiang, P., Yang, M., Urquidi, V., Hoffman, R.M., and Tarin, D. Prolonged dormancy and site-specific growth potential of cancer cells spontaneously disseminated from non-metastatic breast tumors revealed by labeling with green fluorescent protein. Clinical Cancer Res. 9, 3808-3814, 2003.[PDF] 

  57. Yamamoto, N., Yang, M., Jiang, P., Xu, M., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M.  Real-time imaging of individual color-coded metastatic colonies in vivo.  Clin. Exp. Metastasis 20(7), 633-638, 2003.[PDF]

  58. Yamamoto, N., Yang, M., Jiang, P., Xu, M., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M.  Determination of clonality of metastasis by cell-specific color-coded fluorescent-protein imaging.  Cancer Research 63, 7785-7790, 2003. [PDF]  

  59. Yang, M., Li, L., Jiang, P., Moossa, A.R., Penman, S., and Hoffman, R.M.  Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells.  Proc. Natl. Acad. Sci. USA 100, 14259-14262, 2003. [PDF]  

  60. Hoffman, R.M., and Yagi, S. In vivo single-cell imaging. Bio-venture (Japan) 3, 77-78, 2003.

  61. Mitsiades, C.S., Mitsiades, N.S., Bronson, R.T., Chauhan, D., Munshi, N., Treon, P.S., Maxwell, C.A., Pilarski, L., Hideshima, T., Hoffman,R.M. Fluorescent Imaging of Multiple Myeloma Cells in a Clinically Relevant SCID/NOD in vivo Model: Biological and Clinical Implications. Cancer Research 63, 6689-6696, 2003. [PDF].

  62. Katz, M., Spivac, D., Takimoto, S., Bouvet, M., Moosa, A.R., R.M. Hoffman. An imageable highly metastatic orthotopic red fluorescent protein model of pancreatic cancer. Clin. Exp. Metastasis 21, 7-12, 2004.[PDF]

  63. Katz, M.H., Bouvet, M., Takimoto, S., Spivack, D., Moosa, A.R., and Hoffman, R.M. Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer. Cancer Research 64, 1828-1833, 2004. [PDF] 

  64. Hoffman, R. Multicolor in vivo imaging in mouse models of cancer. Preclinica. 2, 109-113, 2004. [PDF]

  65. Robinson, K. Dual-color fluorescence imaging distinguishes tumor from host. Biophotonics Intl., January, 56-57, 2004 [PDF] 

  66. Mihich, E. and Kaelin, W. Fifteenth Annual Pezcoller Symposium: Molecular in vivo visualization of cancer cells. Cancer research 64, 2929-2933, 2004 [PDF] 

  67. Hoffman, R.M. In vivo imaging with fluorescent proteins: The new cell biology. Acta Histochemica 106, 77-87, 2004. [PDF]

  68. Yamamoto, N., Jiang, P., Yang, M., Xu, M., Yamauchi, K., Tsuchiya, H., Tomita, K., Wahl, G.M., Moossa, A.R., and Hoffman, R.M. Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Research 64, 4251-4256, 2004. [PDF]

  69. Yang, M., Amoh, Y., Li, L., Baranov, E., Wang, J-W., Jiang, P., Moossa, A.R., and Hoffman, R.M. Dual-color fluorescence imaging of tumor-host interaction with green and fluorescent proteins. In: Genetically Engineered and Optical Probes for Biomedical Applications II (Savitsky, A.P., Brovko, L.Y., Bornhop, D.J., Raghavachari, R., Achilefu, S.I., eds). Proceedings of SPIE Conference, 5329, 54-60, 2004. [PDF]  

  70. Laakkonen, P., Akerman, M.E., Biliran, H., Yang, M., Ferrer, F., Karpanen, T., Hoffman, R.M., Ruoslani, E. Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc. Natl. Acad. Sci. USA 101, 9381-9386, 2004. [PDF]

  71. Wang, J-W., Yang, M., Yagi, S., and Hoffman, R.M. Oral 5-FU is a more effective antimetastatic agent than UFT. Anticancer Research 24, 1353-1360, 2004. 

  72. Amoh, Y., Li, L., Yang, M., Moosa, A.R., Katsuoka, K., Penman, S., and Hoffman, R.M., Nascent blood vessels in the skin arise from nestin-expressing hair follicle cells. Proc. Natl. Acad. Sci. USA 101, 13291-13295, 2004. [PDF]

  73. Bobek, V. Plachy, J., Pinterova, D., Kolotsova, K., Boubelik, M., Jiang, P. P., Yang, M., and Hoffman R. M. Development of a green fluorescent protein metastatic-cancer chick-embryo drug-screen model. Clinical & Experimental Metastasis 21, 347-352, 2004. [PDF]

  74. Yang, M., Reynoso, J., Jiang, P., Li, L., Moossa, A.R., and Hoffman, R.M.  Transgenic nude mouse with ubiquitous green fluorescent protein _expression as a host for human tumors.  Cancer Research 64, 8651-8656, 2004. [PDF] 

  75. Hoffman, R.M. Imaging tumor angiogenesis with fluorescent proteins. Acta Pathologica, Microbiologica et Immunologica Scandinavica 112, 441-449, 2004. [PDF]

  76. Wang, J., Yang, M., and Hoffman, R.M. Visualizing portal vein metastatic trafficking to the liver with green fluorescent protein-expressing tumor cells. Anticancer Research 24, 3699-3702,2004. [PDF]

  77. Yamamoto, N., Yang, M., Jiang, P., Xu, M., Yamauchi, K., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M. Color coding cancer cells with fluorescent proteins to visualize in vivo cellular interaction in metastatic colonies. Anticancer Research 24, 4067-4072, 2004. [PDF]

  78. Bobek, V., Kolostova, K., Pinterov, D., Boubelik, M., Jiang, P., Yang, M., and Hoffman, R.M. Syngeneic lymph-node-targeting model of green fluorescent protein-expressing Lewis lung carcinoma. Clinical & Experimental Metastasis 21, 705-708, 2004.[PDF]

  79. Zhao, M., Yang, M., Li, X-M., Jiang, P., Li, S., Xu, M., and Hoffman, R.M.  Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium.  Proc. of Natl. Acad. Sci USA 102, 755-760, 2005. [PDF] 

  80. Burton, D.W., Geller, J., Yang, M., Jiang, P., Barken, I., Hastings, R.H., Hoffman, R.M., and Deftos, L.J. Monitoring of skeletal progression of prostate cancer by GFP imaging, X-ray, and serum OPG and PTHrP. The Prostate 62, 275-281, 2005. DOI: 10.1002/pros.20146. [PDF]

  81. Yang, M., Jiang, P., Yamamoto, N., Li, L., Geller, J., Moossa, A.R., and Hoffman, R.M. Real-time whole-body imaging of an orthotopic metastatic prostate cancer model expressing rad fluorescent protein. The Prostate 62, 374-379,2005. DOI #10.1002/pros.20125. [PDF]

  82. Deftos, L.J., Barken, I., Burton, D.W., Hoffman, R.M., and Geller, J. Direct evidence that PTHrP expression promotes prostate cancer progression in bone. Biochem. Biophys. Res. Commun. 327, 468-472, 2005. [PDF]

  83. Amoh, Y., Li, L., Yang, M., Jiang, P., Moossa, A.R., Katsuoka, K., Hoffman, R.M. Hair-follicle-derived blood vessels vascularize tumors in skin and are inhibited by doxorubicin.  Cancer Research 65, 2337-2343, 2005. [PDF] 

  84. Berezovskaya, O., Schimmer, A.D., Glinskii, A.B., Pinilla, C., Hoffman, R.M., Reed, J.C., and Glinky, G.V.  Increased _expression of apoptosis inhibitor protein XIAP contributes to resistance to anoikis of human prostate cancer metastasis precursor cells.  Cancer Research 65, 2378-2386, 2005. [PDF]

  85. Amoh, Y., Li, L., Katsuoka, K., Penman, S., and Hoffman, R.M.  Multipotent nestin-positive, keratin-negative hair-follicle-bulge stem cells can form neurons.  Proc. Natl. Acad. Sci. USA 102, 5530-5534, 2005. [PDF] 

  86. Yamauchi, K., Yang, M., Jiang, P., Yamamoto, N., Xu, M., Amoh, Y., Tsuji, K., Bouvet, M., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M.  Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration.  Cancer Res. 65, 4246-4252, 2005. [PDF] 

  87. Hoffman, R.M.  Imaging of angiogenesis in vivo with fluorescent proteins: fluorescence imaging of angiogenesis.  In: Meadows, Gary G., Ed.  Integration/Interaction of Oncologic Growth.  Book Series: Kaiser, H., Ed.  Cancer Growth and Progression, 2nd Ed., Vol. 15, pp. 37-45.  Dordrecht, The Netherlands: Springer, 2005.  ISBN #1-4020-3413-X. [PDF] 

  88. Amoh, Y., Yang, M., Li, L., Reynoso, J., Bouvet, M., Moossa, A.R., Katsuoka, K., and Hoffman, R.M.  Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis.  Cancer Res. 65, 5352-5357, 2005. [PDF] 

  89. Hoffman, R.M. and Yang, M. Dual-color whole-body imaging in mice. Nature Biotechnology 23, 790-791, 2005. [PDF]

  90. Yang, M., Luiken, G., Baranov, E., and Hoffman, R.M. Facile whole-body imaging of internal fluorescent tumors in mice with an LED flashlight. Bio Techniques 39, 170-172, 2005. [PDF]

  91. Hoffman, R.M. Advantages of multi-color fluorescent proteins for whole-body and in in vivo cellular imaging. Journal of Biomedical Optics 10(4), 41202, AN #041202, 2005. [PDF]

  92. Hoffman, R.M.  The multiple uses of fluorescent proteins to visualize cancer in vivo. Nature Reviews Cancer 5, 796-806, 2005. [PDF] 

  93. Bouvet, M., Spernyak, J., Katz, M.H., Mazurchuk, R.V., Takimoto, S., Bernacki, R., Rustum, Y.M., Moossa, A.R., and Hoffman, R.M. High correlation of whole- body red fluorescent protein imaging and magnetic resonance imaging on an orthotopic model of pancreatic cancer. Cancer Research 65, 9829-9833, 2005. [PDF]

  94. Amoh, Y., Li, L., Campillo, R., Kawahara, K., Katsuoka, K., Penman, S., and Hoffman, R.M. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc. Natl. Acad. Sci. USA 102, 17734-17738,2005. [PDF]

  95. Hoffman, R.M.  In vivo cell biology of cancer cells visualized with fluorescent proteins.  In:  “In vivo cellular and molecular imaging” for Current Topics in Developmental Biology, Vol. 70, pp. 121-144. Ahrens, Eric T., ed.  London: Elsevier Life Sciences, 2005.  DOI: 10.1016/S0070-2153(05)70006-5. [PDF]

  96. Hemman, M.T., Bric, A., Teruya-Feldstein, J., Herbst, A., Nilsson, J.A., Cordon-Cardo, C., Cleveland, J.L., Tansey, W.P., Lowe, S.W. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature 436, 807-811, 2005. [PDF]

  97. Tsuji, K., Yamauchi, K., Yang, M., Jiang, P., Bouvet, M., Endo, H., Kanai, Y., Yamashita, K., Moossa, A.R., and Hoffman, R.M. Dual-color imaging of nuclear-cytoplasmic dynamics, viability, and proliferation of cancer cells in the portal vein area. Cancer Res. 66, 303-306, 2006. [PDF]  Y

  98. Pilch, J., Brown, D.M., Komatsu, M., Jarvinen, T., Yang, M., Peters, D., Hoffman, R.M., and Ruoslahti, E. Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc. Natl. Acad. Sci. USA 103, 2800-2804, 2006.

  99. Glinsky, G.V., Glinski, A.B., Berezovskaya, O., Smith, B.A., Jiang, P., Li, X-M., Yang, M., Hoffman, R.M. Dual color-coded imaging of viable circulating prostate carcinoma cells reveals genetic exchange between tumor cells in vivo, contributing to highly metastatic phenotypes. Cell Cycle 5, 191-197, 2006.

  100. Tsuji, K., Yamauchi, K., Jiang, P., Yang, M., and Hoffman, R.M. Common bile duct injection as a novel method for establishing RFP-expressing human pancreatic cancer in nude mice. Journal of the Pancreas 7, 193-199, 2006. 

  101. Yamauchi, K., Yang, M., Jiang, P., Xu, M., Yamamoto, N., Tsuchiya, H., Tomita, K., Moosa, A.R., Bouvet, M., and Hoffman, R.M. Development of real-time subcellular dynamic multicolor imaging of cancer cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res. 66, 4208-4214, 2006. [PDF]

  102. Yang, M., Burton, D.W., Geller, J., Hillegonds, D., Hastings, R.H., Deftos, L.J., and Hoffman, R.M. The bisphosphanate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model. Clinical Cancer Research 12, 2602-2606, 2006.

  103. Amoh, Y., Li, L., Tsuji, K., Moosa, A.R., Katsuoka, K., Hoffman, R.M., Bouvet, M. Dual-color imaging of nascent blood vessels vascularizing pancreatic cancer in an orthotopic model demonstrates antioangiogenesis efficacy of gemcitabine. J. Surgical Research 132, 164-169, 2006. 

  104. Liu, T., Ding, Y., Xie, W., Li, Z., Bai, X., Li, X., Fang, W., Ren, C., Wang, S., Hoffman, R.M., and Yao, K.  An imageable metastatic treatment model of nasopharyngeal carcinoma.  Clin. Cancer Res. 13, 3960-3967, 2007.[PDF]

 

Kidney

  1. An, Z., Jiang, P., Wang, X., Moossa, A.R., and Hoffman, R.M. Development of a high metastatic orthotopic model of human renal cell carcinoma in nude mice: Benefits of fragment implantation compared to cell-suspension injection.  Clinical & Experimental Metastasis 17, 265-270, 1999. [PDF]

 

Liver

  1. Sun, F.X., Tang, Z.Y., Liu, K.D., Ye, S.L., Xue, Q., Gao, D.M., and Ma, Z.C.  Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues. Int. J. Cancer 66, 239-243, 1996. [PDF] 

  2. Sun, F-X., Tang, Z-Y., Liu, K-D., Xue, Q., Gao, D-M., Yu, Y-Q., Zhou, X-D., Ma, Z-C.  Metastatic models of human liver cancer in nude mice orthotopically constructed by using histologically intact patient specimens.  J. Cancer Res. Clin. Oncol. 122, 397-402, 1996. [PDF]

  3. Rashidi, B., An, Z., Sun, F-X, Li, X-M., Tang, Z.Y., Moossa, A.R., and Hoffman, R.M.  Efficacy of intra-hepatectomy 5-FU on recurrence and metastasis of human hepatocellular carcinoma in nude mice.  Int. J. Cancer 91, 231-235, 2001. [PDF]  

  4. Wu, M., Mazarchuk, R., Chaudhary, N.D., Spernyak, J., Veith, J., Pera, P., Greco, W., Hoffman, R.M., Kobayashi, T., and Bernacki, R.J. High Resolution Magnetic Resonance Imaging of the Efficacy of the Cytosine Analogue 1-[2-C-Cyano-2-deoxy-b-D-arabino-pentofuranosyl]-N4 - palmitoyl Cytosine (CS-682) in a Liver-Metastasis Athymic Nude Mouse Model. Cancer Res. 63, 2477-2482, 2003. [PDF] 

Lung

  1. Wang, X., Fu, X., and Hoffman, R.M.  A new patient-like metastatic model of human lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice.  Int. J. Cancer 51, 992-995, 1992. [PDF]

  2. Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S., Tanino, H., Nishibori, K., Saikawa, Y., Teramoto, T., Ishibiki, K., Kitajima, M., and Hoffman, R.M.  Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice.  Anticancer Res. 12, 1407-1410, 1992.[PDF]

  3. Wang, X., Fu, X., and Hoffman, R.M.  A patient-like metastasizing model of human lung adenocarcinoma constructed via thoracotomy in nude mice.  Anticancer Res. 12, 1399-1402, 1992. [PDF]

  4. Wang, X., Fu, X., Kubota, T., and Hoffman, R.M.  A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in nude mice.  Anticancer Res. 12, 1403-1406, 1992. [PDF]

  5. Kuo, T-H., Kubota, T., Watanabe, M., Furukawa, T., Kase, S., Tanino, H., Saikawa, Y., Ishibiki, K., Kitajima, M., and Hoffman, R.M.  Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice: the importance of orthotopic models to obtain relevant drug evaluation data.  Anticancer Res. 13, 627-630, 1993. [PDF]

  6. Astoul, P., Wang, X., and Hoffman, R.M.  "Patient-like" nude- and SCID-mouse models of human lung and pleural cancer (Review).  Int. J. Oncology  3, 713-718, 1993. [PDF]

  7. Astoul, P., Colt, H.G., Wang, X., and Hoffman, R.M.  A “patient-like” nude mouse model of parietal pleural human lung adenocarcinoma.  Anticancer Res. 14, 85-92, 1994.

  8. Astoul, P., Colt, H.G., Wang, X., Boutin, C. and Hoffman, R.M.  A “patient-like” nude mouse metastatic model of  advanced human pleural cancer.  Journal of Cellular Biochemistry 56, 9-15, 1994.[PDF] 

  9. Astoul, P., Wang, X., Colt, H.G., Boutin, C., and Hoffman, R.M.  A patient-like human malignant pleural mesothelioma nude-mouse model.  Oncology Reports 3, 483-487, 1996.

  10. Colt, H.G., Astoul, P., Wang, X., Yi, E.S., Boutin, C., and Hoffman, R.M.  Clinical course of human epithelial-type malignant pleural mesothelioma replicated in an orthotopic-transplant nude mouse model.   Anticancer Res. 16, 633-640, 1996. [PDF] 

  11. An, Z., Wang, X., Astoul, P., Danays, T., Moossa, A.R., and Hoffman, R.M.  Interferon gamma is highly effective against orthotopically-implanted human pleural adenocarcinoma in nude mice.  Anticancer Res. 16, 2545-2551, 1996. [PDF]

  12. Olbina, G., Cieslak, D., Ruzdijic, S., Esler, C., An, Z., Wang, X., Hoffman, R., Seifert, W., and Pietrzkowski, Z. Reversible inhibition of IL-8 receptor B mRNA expression and proliferation in non-small cell lung cancer by antisense oligonucleotides.  Anticancer Res. 16, 3525-3530, 1996. [PDF]

  13. Yang, M., Hasegawa, S., Jiang, P., Wang, X., Tan, Y., Chishima, T., Shimada, H., Moossa, A.R., and Hoffman, R.M.  Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression.  Cancer Res. 58, 4217-4221, 1998. [PDF]

  14. Rashidi, B., Yang, M., Jiang, P., Baranov, E., An, Z., Wang, X., Moossa, A.R., and Hoffman, R.M.  A highly metastatic Lewis lung carcinoma orthotopic green fluorescent protein model.  Clinical & Experimental Metastasis 18, 57-60, 2000. [PDF] 

  15. Hoffman, Robert M.  Metastatic Mouse Models of Lung Cancer.  In: Driscoll, B., ed.  Methods in Molecular Medicine, Vol. 74: Lung Cancer, Vol. 1: Molecular Pathology Methods and Reviews.  Totowa, NJ: Humana Press, 457-464, 2002.. [PDF]

  16. Yamamoto, N., Yang, M., Jiang, P., Tsuchiya, H., Tomita, K., Moossa, A.R., and Hoffman, R.M.  Real-time GFP imaging of spontaneous HT-1080 fibrosarcoma lung metastases.  Clin. Exp. Metastasis 20, 181-185, 2003. [PDF] 

  17. Bobek, V., Boubelik, M., Fiserova, A., L'uptovcova, M., Vannucci, L., Kacprzak, G., Kolodzej, J., Majevski, A.M., and Hoffman R.M. Anticoagulant drugs increase natural killer cell activity in lung cancer. Lung Cancer 47, 215-223, 2005. 

 

Multiple Myeloma

  1. Mitsiades, C.S., Mitsiades, N.S., Bronson, R.T., Chauhan, D., Munshi, N., Treon, P.S., Maxwell, C.A., Pilarski, L., Hideshima, T., Hoffman,R.M. Fluorescent Imaging of Multiple Myeloma Cells in a Clinically Relevant SCID/NOD in vivo Model: Biological and Clinical Implications. Cancer Research 63, 6689-6696, 2003. [PDF].

  2. Amoh, Y., Li, L., Yang, M., Jiang, P., Moossa, A.R., Katsuoka, K., Hoffman, R.M. Hair-follicle-derived blood vessels vascularize tumors in skin and are inhibited by doxorubicin.  Cancer Research 65, 2337-2343, 2005. [PDF] 

Nasopharyngeal Carcinoma

  1. Liu, T., Ding, Y., Xie, W., Li, Z., Bai, X., Li, X., Fang, W., Ren, C., Wang, S., Hoffman, R.M., and Yao, K.  An imageable metastatic treatment model of nasopharyngeal carcinoma.  Clin. Cancer Res. 13,     3960-3967, 2007.[PDF]

Ovarian

  1. Fu, X., and Hoffman, R.M.  Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens.  Anticancer Res. 13, 283-286, 1993.[PDF]

  2. Astoul, P., Colt, H.G., Wang, X., and Hoffman, R.M.  Metastatic human pleural ovarian cancer model constructed by orthotopic implantation of fresh histologically-intact patient carcinoma in nude mice.  Anticancer Res. 13, 1999-2002, 1993. [PDF]

  3. Kiguchi, K., Kubota, T., Aoki, D., Udagawa, Y., Yamanouchi, S., Saga, M., Amemiya, A., Nozawa, S., Moossa, A.R., and Hoffman, R.M.  A patient-like orthotopic implantation nude mouse model of highly metastatic human ovarian cancer. Clinical & Experimental Metastasis 16, 751-756, 1998. [PDF]

Pancreas

  1. Fu, X., Guadagni, F., and Hoffman, R.M.  A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically from histologically intact patient specimens.  Proc. Natl. Acad. Sci. USA 89, 5645-5649, 1992. [PDF] 

  2. Furukawa, T., Kubota, T., Watanabe, M., Kitajima, M., and Hoffman, R.M.  A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice.  Cancer Res. 53, 3070-3072, 1993.

  3. An, Z., Wang, X., Kubota, T., Moossa, A.R., Hoffman, R.M.  A clinical nude mouse metastatic model for highly malignant human pancreatic cancer.  Anticancer Res. 16, 627-631, 1996.

  4. Tomikawa, M., Kubota, T., Matsuzaki, S.W., Takahasi, S., Kitajima, M., Moossa, A.R., and Hoffman, R.M.  Mitomycin C and cisplatin increase survival in a human pancreatic cancer metastatic model.  Anticancer Res. 17, 3623-3626, 1997.

  5. Bouvet, M., Yang, M., Nardin, S., Wang, X., Jiang, P., Baranov, E., Moossa, A.R., Hoffman, R.M.  Chronologically-specific metastatic targeting of human pancreatic tumors in orthotopic models.  Clinical & Experimental Metastasis 18, 213-218, 2000.

  6. Lee, N.C., Bouvet, M., Nardin, S., Jiang, P., Baranov, E., Rashidi, B., Yang, M., Wang, X., Moossa, A.R., and Hoffman, R.M.  Antimetastatic efficacy of adjuvant gemcitabine in a pancreatic cancer orthotopic model. Clinical & Experimental Metastasis 18, 379-384, 2001.[PDF] 

  7. Bouvet, M., Wang, J-W., Nardin, S.R., Nassirpour, R., Yang, M., Baranov, E., Jiang, P., Moossa, A.R., and Hoffman, R.M.  Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model.  Cancer Research 62, 1534-1540, 2002. [PDF]

  8. Bouvet, M., Nardin, S.R., Burton, D.W., Lee, N.C., Yang, M., Wang, X., Baranov, E., Behling, C., Moossa, A.R., Hoffman, R.M., and Deftos L.J.  Parathyroid hormone-related protein as a novel tumor marker in pancreatic adenocarcinoma.  Pancreas