1.
Freeman, A., and Hoffman, R.M. In vivo-like growth of human tumors
in vitro. Proc. Natl. Acad. Sci. USA 83, 2694-2698, 1986.
2.
Vescio, R.A., Redfern, C.H., Nelson, T.J., Ugoretz, S., Stern, P.H., and
Hoffman, R.M. In vivo-like drug response of human
tumors growing in three-dimensional, gel-supported, primary culture. Proc. Natl. Acad. Sci. USA 84, 5029-5033, 1987.
3.
Hoffman, R.M., Monosov, A.Z., Connors, K.M., Herrera, H., and Price, J.H. A general native-state method
for determination of proliferation capacity of human normal and tumor tissues in vitro. Proc. Natl. Acad. Sci. USA 86, 2013-2017, 1989.
4.
Wallen, J.W., Cate, R.L., Kiefer, D.M., Riemen, M.W., Martinez, D.,
Hoffman, R.M., Donahoe, P.K., Von Hoff, D.D., Pepinsky, B., and A. Oliff. Minimal antiproliferative effect of
recombinant Mullerian Inhibiting Substance on gynecological tumor cell lines and
tumor explants. Cancer Res. 49, 2005-2011, 1989.
5.
Vescio, R.A., Connors, K.M., Youngkin, T., Bordin, G.M., Robb, J.A.,
Umbreit, J.N., and Hoffman, R.M.
Cancer biology for individualized cancer therapy: Correlation of growth
fraction index in native-state culture with tumor grade and stage. Proc. Natl. Acad. Sci. USA 87, 691-695, 1990.
6.
Vescio, R.A., Connors, K.M., Bordin, G.M., Robb, J.A., Youngkin, T.,
Umbreit, J.N., and Hoffman, R.M.
The distinction of small cell and non-small cell cancer by growth in
native-state histoculture. Cancer
Res. 50, 6095-6099, 1990.
7.
Robbins, K.T., Varki, N.M., Storniolo, A.M., Hoffman, H., and Hoffman,
R.M. Drug response of head and neck
tumors in native-state histoculture.
Archives of Otolaryngology Head and Neck Surg. 117, 83-86, 1991.
8.
Hoffman, R.M.
Three-dimensional gel-supported native-state histoculture for evaluation
of tumor-specific pharmacological activity: Principles, practices and
possibilities. J. Cell. Pharmacol.
2, 189-201, 1991.
9.
Li, L., Hoffman, R.M. Eye
tissues grown in 3-dimensional histoculture for toxicological studies. J. Cell. Pharmacol. 2, 311-316, 1991.
10.
Hoffman, R.M.
Three-dimensional histoculture: Origins and applications in cancer
research. Cancer Cells 3, 86-92, 1991.
11.
Hoffman, R.M. In vitro sensitivity assays in cancer: A
review, analysis and prognosis. J.
Clin. Lab. Anal. 5, 133-143,
1991.
12.
Vescio, R.A., Connors, K.M., Kubota, T., and Hoffman, R.M. Correlation of histology and drug
response of human tumors grown in native-state three-dimensional histoculture
and in nude mice. Proc. Natl. Acad. Sci. USA 88, 5163-5166, 1991.
13.
Guadagni, F., Roselli, M., and Hoffman, R.M. Maintenance of expression of tumor
antigens in three-dimensional in
vitro human tumor gel-supported histoculture. Anticancer Res. 11, 543-546, 1991.
14.
Baibakov, B., Frank, G.A., Sergeeve, N., Youngkin, T., Connors, K.M.,
Hoffman, R.M., and Margolis, L.B. In vivo growth patterns of human lung
tumors in three-dimensional histoculture.
In Vitro Cell. Dev. Biol. 27A, 897-899, 1991.
15.
Furukawa, T., Kubota, T., Watanabe, M., Takahara, T., Yamaguchi, H.,
Takeuchi, T., Kase, S., Kodaira, S., Ishibiki, K., Kitajima, M., and Hoffman,
R.M. High in vitro-in vivo correlation of drug
response using sponge-gel-supported three-dimensional histoculture and the MTT
end point. Int. J. Cancer 51, 489-498, 1992.
16.
Guo, H.Y., Colangelo, D., Li, L., Connors, K.M., Kubota, T., and Hoffman,
R.M. In vitro histoculture of human tumors
with fluorescent dye end-points measured by confocal microscopy: high
correlation of in vitro and in vivo chemosensitivity. Anticancer Research 12, 1055-1062, 1992.
17.
Guadagni, F., Li, L., and Hoffman, R.M. Targeting antibodies to live tumor
tissue in 3-D histoculture. In
Vitro Cell. Dev. Biol. 28A, 297-299,
1992.
18.
Colangelo, D, Guo, H-Y, Silvestro, L., and Hoffman, R.M. Noncolorimetric measurement of cell
activity in three-dimensional histoculture using the tetrazolium dye
3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide: the pixel image
analysis of formazan crystals.
Anal. Biochem. 205, 8-13,
1992.
19.
Slocum, H.K., Toth, K. Li, L., Chang, S.G, Hoffman, R.M., and Rustum, Y.M. Long-term passage of human
tissues in vitro as three-dimensional
histolines. In Vitro Cell. Dev.
Biol. 28A, 573-577, 1992.
20.
Colangelo, D., Guo, Y.H., Connors, K.M., Kubota, T., Silvestro, L., and
Hoffman, R.M. Correlation of drug
response in human tumors histocultured in
vitro with an image-analysis MTT end point and in vivo xenografted in nude mice.
Anticancer Res. 12, 1373-1376,
1992.
21.
Geller, J., Sionit, L.R., Connors, K.M., and Hoffman, R.M. Measurement of androgen sensitivity in
the human prostate in in vitro
three-dimensional histoculture. The
Prostate 21, 269-278, 1992.
22.
Chang, S.G., Slocum, H., Toth, K., Hoffman, R.M., Perrapato, S.D., Huben,
R.P., and Rustum, Y.M. Glucose
consumption end point in primary histoculture indicates recovery of human tumors
from drug treatment. In Vitro Cell.
Dev. Biol. 28A, 585-587, 1992.
23.
Hoffman, R.M. Histoculture
and the immunodeficient mouse come to the cancer clinic: Rational approaches to
individualizing cancer therapy and new drug evaluation (Review). International Journal of Oncology 1, 467-474, 1992.
24.
Hoffman, R.M. To do tissue
culture in two or three dimensions?
That is the question. Stem
Cells 11, 105-111, 1993.
25.
Theodorescu, D., Connors, K.M., Groce, A., Hoffman, R.M., and Kerbel, R.S. Lack of influence of
c-Ha-ras expression on the drug
sensitivity of human bladder cancer histocultured in three dimensions. Anticancer Res. 13, 941-946, 1993.
26.
Hoffman, R.M. In vitro assays for chemotherapy
sensitivity. Crit. Rev. in
Onc/Hem. 15, 99-111, 1993.
27.
Geller, J., Sionit, L.R., Connors, K.M., Youngkin, T., and Hoffman, R.M. Expression of
prostate-specific antigen in human prostate specimens in in vitro three dimensional histoculture. In Vitro Cell. Dev.
Biol. 29A, 523-524, 1993.
28.
Chang, S.G., Chai, S.O., Kim, E.S, Yoon, C., Joo, H.Z., and Hoffman, R.M. The measurement of glucose
consumption in histoculture to determine effects of doxorubicin and cisplatinum
on human gastric carcinoma. Anticancer Res. 13, 1303-1310, 1993.
29.
Tanino, H., Kubota T., Saikawa, Y., Kuo, T-H., Takeuchi, T., Kase, S.,
Kurukawa, T., Kitajima, M. Saurai, T., Naito, Y. and Hoffman, R.M. Different chemo- and endocrino-sensitivity of MCF‑7 cells with or without estradiol supplement in vitro. Anticancer Res. 13, 1219-1222, 1993.
30.
Robbins, T., Connors, K.M., Storniolo, A.M., Hanchett, C., and Hoffman,
R.M. Sponge-gel supported
histoculture drug-response assay for head and neck cancer: Correlations with
clinical response to cisplatin.
Arch. Otol. Head & Neck Surg. 120, 288-292, 1994.
31.
Chang, S.G., Lee, J.H., Hong, D.H., Lee, H.Y., Chai, S.E. and Hoffman,
R.M. Comparison of
glucose-consumption and thymidine-incorporation endpoints on histocultured human
superficial bladder tumor.
Anticancer Res. 14, 77-83,
1994.
32.
Hoffman, R.M. The
three-dimensional question: can clinically relevant tumor drug resistance be
measured in vitro? Cancer and
Metastasis Reviews 13, 169-173,
1994.
33.
Geller, J., Sionit, L.R., Baird, A., Kohls, M., Connors, K.M., and
Hoffman, R.M. In vivo and in vitro
effects of androgen on FGF-2 concentrations in the human prostate. The Prostate 25, 206-209, 1994.
34.
Furukawa, T., Kubota, T., Hoffman, R.M. Clinical applications of the
histoculture drug response assay.
Clinical Cancer Research 1,
305-311, 1995.
35.
Kubota, T., Sasano, N., Abe, O., Nakao, I., Kawamura, E., Saito, T.,
Endo, M., Kimura, K., Demura, H., Sasano, H., Nagura, H., Ogawa, N., and
Hoffman, R.M. Potential of the
histoculture drug response assay to contribute to cancer patient survival. Clinical Cancer Research 1, 1537-1543, 1995.
36.
Hoffman, R.M. In vitro drug
response assays for entry into the rational era cancer chemotherapy. Human Cell 8, Japan Human Cell Society, 131-148,
1995.
37.
Hoffman, R.M. Can in vitro drug response assays be
clinically useful? Problems and
solutions. Biotherapy 10, 822-842, 1996.
38.
Chang, S-G., Jung, J-C., Rho, Y-S., Huh, J-S., Kim, J-I., and Hoffman,
R.M. Efficacy of the platinum
analog {Pt(cis-dach)(DPPE) - 2NO3} on histocultured human patient
bladder tumors and cancer cell lines.
Anticancer Res. 16,
3423-3428, 1996.
39.
Chang, S-G., Lee, S.J., Lee, S-J., Kim, J.I., Jung, J-C. and Hoffman, R.M. Interleukin-6 production in
primary histoculture by normal human kidney and renal tumors tissues. Anticancer Res. 17, 113-116, 1997.
40.
Geller, J., Partido, C., Sionit, L., Youngkin, T., Espanol, M., Tan, Y.,
and Hoffman, R.M. Comparison of
androgen-independent growth and androgen-dependent growth in BPH and cancer
tissue from the same radical prostatectomies in sponge-gel matrix histoculture. The Prostate 31, 250-254, 1997.
41.
Hoffman, R.M.
Taking chemotherapy from random to rational with the histoculture drug response assay.
Jpn. J. Cancer Chemother. 24, 206-229, 1997.
42.
Chishima, T., Yang, M., Miyagi, Y., Li, L., Tan, Y., Baranov, E.,
Shimada, H., Moossa, A.R., Penman, S., and Hoffman, R.M. Governing step of metastasis visualized
in vitro. Proc. Natl. Acad. Sci. USA 94, 11573-11576, 1997.
43.
Chishima, T., Miyagi, Y., Li, L., Tan, Y., Baranov, E., Yang, M.,
Shimada, H., Moossa, A.R., and Hoffman, R.M. The use of histoculture and green
fluorescent protein to visualize tumor cell host interaction. In Vitro Cell. Dev. Biol. 33, 745-747, 1997.
44. Geller, J., Sionit, L., Partido, C., Li, L., Tan, X-Y., Youngkin, T., Nachtsheim, D., and Hoffman, R.M. Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. The Prostate 34, 75-79, 1998 [PDF]
45. Hoffman, R.M. Three-dimensional sponge-gel matrix histoculture of human tumors: Methods and applications. In: Cell Biology, A Laboratory Handbook 1, 367-379, Ed: J. Celis, San Diego: Academic Press, 1994. [PDF]
46.
Hoffman, R.M.
Three-dimensional sponge-gel matrix histoculture of human tumors: Methods and applications. In: Cell
Biology, A Laboratory Handbook 2(1),
377-389, Ed: J. Celis, San Diego: Academic Press, 1998.
47.
Olbina, G., Miljkovic, D., Hoffman, R.M., and Geller, J. New sensitive discovery histoculture
model for growth-inhibition studies in prostate cancer and BPH. The Prostate 37, 126-129, 1998.
48.
Haran, C. Custom chemo. MAMM, 49-53, September/October
1999.
49.
Hoffman, R.M. The clinical
benefit of the histoculture drug response assay. Jpn. J. Cancer Chemother 27, Supplement 11, 321-322, 2000.
50. Ohie, S., Udagawa, Y., Kozu, A., Komuro, Y., Aoki, D., Nozawa, S., Moossa, A.R., and Hoffman, R.M. Cisplatin sensitivity of ovarian cancer in the histoculture drug response assay correlates to clinical response to combination chemotherapy with cisplatin, doxorubicin, and cyclophosphamide. Anticancer Research 20, 2049-2054, 2000. [PDF]
51. Furukawa, T., Kubota, T., Tanino, H., Oura, S., Yuasa, S., Murate, H., Morita, K., Kozakai, K., Yano, T., and Hoffman, R.M. Chemosensitivity of breast cancer lymph node metastasis compared to the primary tumor from individual patients tested in the histoculture drug response assay. Anticancer Research 20, 3657-3658, 2000. [PDF]
52.
Hoffman, R.M. Histocultures and
Organ Cultures. In: Encyclopedia of Life Sciences, http://www.els.net/, London: Nature Publishing
Group, 2001.
53. Tanino, H., Oura, S., Hoffman, R.M., Kubota, T., Furukawa, T., Arimoto, J., Yoshimasu, T., Hirai, I., Bessho, T., Suzuma, T., Sakuari, T., and Naito, Y. Acqusition of multidrug resistance in recurrent breast cancer demostrated by the histoculture drug response assay. Anticancer Res. 21, 4083-4086, 2001. [PDF]
54. Singh, B., Li, R., Xu, L., Poluri, A., Patel, S., Shaha, A. S., Pfister, D., Sherman, E., Goberdhan, A., Hoffman, R. M., Shah, J.Prediction of survival in patients with head and neck cancer using the histoculture drug response assay. 24, Head&Neck. 437-442, 2002 [PDF]
55. Flowers, JL., Hoffman, R.M., Driscoll, T.A., Wall, M.E., Wani, M.C., Manikumar, G., Friedman, H.S., Dewhirst, M., Colvin, O.M., Adams, D.J. The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH. Cancer Chemotherapy and Pharmacology 52, 253-261, 2003. [PDF]