DermaTek® Publications:
1.
Hoffman, R.M., Margolis, L.B., and
Bergelson, L.D. Binding and entrapment of high molecular weight DNA by lecithin
liposomes. Elsevier/North-Holland Biomedical Press, FEBS Letters 93,
365-368, 1978.
2.
Li, L., Margolis, L.B., and Hoffman,
R.M. Native-state sponge-gel histoculture of intact 3-dimensional tissue for
in vitro toxicity assays. 8th International CAAT Symposium, (ed.) Alan M.
Goldberg, The Johns Hopkins University. Alternative Methods in Toxicology 8,
311-316, 1991.
3.
Li, L., and Hoffman, R.M. Hair
growth and hair follicle proliferation in histocultured mouse skin. Annals of
the New York Academy of Sciences, The Molecular and Structural Biology of
Hair 642, 506-509, 1991.
4.
Li, L., Margolis, L.B. and Hoffman,
R.M. Skin toxicity determined in vitro by three-dimensional,
native-state histoculture. Proc. Natl. Acad. Sci. USA 88, 1908-1912,
1991.
5.
Li, L., Paus, R., Margolis, L.B., and
Hoffman, R.M. Hair growth in vitro from histocultured skin. In Vitro
Cell. Dev. Biol. 28A, 479-481, 1992.
6.
Li, L., Paus, R., Margolis, L.B., and
Hoffman, R.M. Hair shaft elongation, follicle growth, and spontaneous
regression in long-term, gelatin sponge-supported histoculture of human scalp
skin. Proc. Natl. Acad. Sci. USA 89, 8764-8768, 1992.
7. Li, L., Paus, R., Slominski, A., and Hoffman, R.M. Skin histoculture assay for studying the hair cycle. In Vitro Cell. Dev. Biol. 28A, 695-698, 1992. [PDF]
8.
Li, L., Lishko, V.K., Margolis, L.B.,
and Hoffman, R.M. Product-delivering liposomes specifically target hair
follicles in histocultured intact skin. In Vitro Cell. Dev. Biol. 28A,
679-681, 1992.
9.
Li, L., Lishko, V.K., and Hoffman,
R.M. Liposomes can specifically target entrapped melanin to hair follicles in
histocultured skin. In Vitro Cell Dev. Biol. 29A, 192-194, 1993.
10.
Li, L., Lishko, V.K., and Hoffman,
R.M. Liposome targeting of high molecular weight DNA to the hair follicles of
histocultured skin: A model for gene therapy of the hair growth processes. In
Vitro Cell Dev. Biol. 29A, 258-260, 1993.
11.
Li, L. and Hoffman, R.M.
Histoculture radiometric in vitro hair growth assay. In Vitro Cell. Dev.
Biol. 29A, 449-450, 1993.
12.
Li, L., Lishko, V., and Hoffman, R.M.
High efficiency liposome-mediated transfection of the tyrosinase gene to
cultured cells: A model for the gene therapy of hair color restoration. In
Vitro Cell. Dev. Biol. 30A, 135-138, 1994.
13.
Paus, R., Kreja-Papa, N., Li, L.,
Czarnetski, B.M., and Hoffman, R.M. Correlation of proteolytic activities of
organ cultured intact mouse skin with defined hair cycle stages. J. Derm. Sci.
7, 202-209, 1994.
14.
Li, L. and Hoffman, R.M. Model of
selective gene therapy of hair growth: liposome targeting of the active Lac-Z
gene to hair follicles of histocultured skin. In Vitro Cell Dev. Biol. 31A,
11-13, 1995.
15. Li, L. and Hoffman, R.M. The feasibility of targeted selective gene therapy of the hair follicle. Nature Medicine 1, 705-706, 1995. [PDF]
16.
Zhang, L., Li, L., Hofmann, G.A., and
Hoffman, R.M. Depth-targeted efficient gene delivery and expression in the skin
by pulsed electric fields: an approach to gene therapy of skin aging and other
diseases. Biochemical and Biophysical Research Communications 220,
633-636, 1996.
17.
Li, L. and Hoffman, R.M. Topical
liposome delivery of molecules to hair follicles in mice. J. Derm. Sci. 14,
101-108, 1997.
18.
Zhang, L., Li, L., An, Z., Hoffman,
R.M., and Hofmann, G.A. In vivo transdermal delivery of large molecules
by pressure-mediated electroincorporation and electroporation: a novel method
for drug/gene delivery. Bioelectrochemistry and Bioenergetics 42,
283-292, 1997.
19.
Hoffman, R.M. Topical liposome
targeting of dyes, melanins, genes, and proteins selectively to hair follicles.
J. Drug Targeting 5, 67-74, 1997.
20.
Gene scientists give grey hair the
brush-off. The Sunday Times, London, 19 September 1999.
21.
Hoffman, R.M. The hair follicle as a
gene therapy target. Nature Biotechnology 18, 20-21, 2000.
22.
Wadmar, M. Wash that gray right out
of your hair. Fortune, p. 40, February 7, 2000.
23.
Friedman, Devin. Tech 2010, A
Catalog of the Near Future; The Makeup That Changes Your Identity. The New York
Times Magazine, p. 56-57, June 11, 2000.
24. Zhao, M., Saito, N., Li, L., Baranov, E., Kondoh, H., Mishima, Y., Sugiyama, M., Katsuoka, K., Hoffman, R.M. A novel approach to gene therapy of albino hair in histoculture with a retroviral Streptomyces tyrosinase gene. Pigment Cell Research 13, 345-351, 2000. [PDF]
25. Saito, N., Zhao, M., Li.L., Baranov, E., Yang, M., Ohta, Y., Katsuoka, K., Penman, S., and Hoffman R.M. High efficiency genetic modification of hair follicles and growing hair shafts. Proc. Natl. Acad. Sci USA 99, 1310-1314, 2002. [PDF]
26. Hoffman, R.M. Immune reactions in skin anfd hair follicle gene therapy. Molecular Therapy 7, 294-295, 2003. [PDF]
27. Li, L., Mignone, J., Yang. M., Matic, M., Penman, S., Enikolopov, G. Nestin Expression in hair follicle sheath progenitor cells. Proc. Natl. Acad. Sci. USA 100(17), 9958-9961, 2003. [PDF]
28. Hoffman, R.M. Gene targeting of hair follicles. In: Hair Science and Technology, ISBN 2-9600376-0-X, pp.363-372. Van Neste, D., ed. Tournai, Belgium: Skinterface, 2003.
29. Amoh, Y., Li, L., Yang, M., Moossa, A.R., Katsuoka, K., Penman, S., and Hoffman, R.M. Nascent blood vessels in the skin arise from nestin-expressing hair follicle cells. Proc. Natl. Acad. Sci. USA 101, 13291-13295, 2004 [PDF]
30. Amoh, Y., Li, L., Yang, M., Jiang, P., Moossa, A.R., Katsuoka, K., Hoffman, R.M. Hair-follicle-derived blood vessels vascularize tumors in skin and are inhibited by doxorubicin. Cancer Research 65, 2337-2343, 2005 [PDF]
31. Hoffman, R.M. Gene and stem cell therapy of the hair follicle. In: Epidermal Cells: Methods and Protocols. Methods in Molecular Biology, Vol. 289, pp. 437-448. Turksen, K., ed. Totowa, NJ: Humana Press, 2005.[PDF]
32. Hoffman, R. M. The hair follicle and its stem cells as drug delivery targets. Expert Opinion Drug Delivery 3, 437-443, 2006 [PDF]