A/C Diagnostics Publications:

Enzymatic Homocysteine Assay

  1. Han et al. High expression, purification and properties of recombinant homocysteine, a, g-lyase. Protein Expression and Purification 14, 267-274, 1998. [PDF] 

  2. Tan et al. Total-homocysteine enzymatic assay. Clinical Chemistry 46, 1686-1688, 2000. [PDF] 

  3. Nygard et al. Plasma homocysteine levels and mortality in patients with coronary artery disease. New Engl. J. Med. 337, 230-236, 1997.

  4. Schnyder et al. Association of plasma homocysteine with the number of major coronary arteries severely narrowed. Am. J. Cardiol. 88, 1027-1030, 2001. 

  5. Tice et al. Cost-effectiveness of vitamin therapy to lower plasma homocysteine levels for the prevention of coronary heart disease: effect of grain fortification and beyond. JAMA 286, 936-943, 2001. 

  6. Glowinska et al. Elevated concentrations of homocysteine in children and adolescents with arterial hypertension accompanying Type 1 diabetes. Med. Sci. Monit. 7, 1242-1249, 2001. 

  7. Rosenberg IH. B vitamins, homocysteine, and neurocognitive function. Nutr. Rev. 59, S69-73; disc. S73-74, 2001. 

  8. Vollset et al. Plasma total homocysteine and cardiovascular and noncardiovascular mortality: the Hordaland Homocysteine Study. Am. J. Clin. Nutr. 74, 130-136, 2001. 

  9. Malinow MR. Plasma concentrations of total homocysteine predict mortality risk. Am. J. Clin. Nutr. 74, 3, 2001. 

  10. Zhang et al. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J. Biol. Chem. 276, 35867-35874, 2001. 

  11. Thambyrajah et al. A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease. J. Am. Coll. Cardiol. 37, 1858-1863, 2002

  12. Tripodi, A., Chantarangkul, V., Tan, Y., Hoffman, R.M., and Cattaneo, M. Evaluation of of an Enzymatic Method to Measure Total Homocysteine in Plasma. Thrombosis and Haemostasis 87, 172-173, 2002

  13. Han, Q., Xu, M., Tang, L., Tan, X-Z., Tan, X-Y., Tan, Y., and Hoffman, R.M. Homogeneous nonradioactive enzymatic assay for plasma pyridoxal 5-phosphate. Clinical Chemistry 48, 1560-1564, 2002. [PDF] 

  14. Tan, Y., Sun, X., Tang, L., Zhang, N., Han, Q., Xu, M., Tan, X., Tan, X., Hoffman, R.M. Automated enzymatic assay for homocysteine. Clinical Chemistry 49, 1029-1030, 2003. [PDF]

Vitamin B6 Enzymatic Assay

1.       Rimm et al.  Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 279, 359-364, 1998.

2.       Selhub et al. Association between plasma homocysteine concentrations and extracranial carotidartery stenosis.  N. Engl. J. Med. 332, 286-291, 1995.

3.       Verhoef et al.  Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate. Am. J. Epidemiol. 143, 845-859, 1996.

4.       Chasan-Taber et al.  A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians.  J. Am. Coll. Nutr. 15, 136-143, 1996.

5.       Cattaneo et al.  Low plasma levels of vitamin B6 are independently associated with a heightened risk of deep-vein thrombosis. Circulation 104, 2442-2446, 2001.

6.       Friso et al. Low circulating vitamin B6 is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation 103, 2788-2791, 2001.

7.       Han et al. High expression, purification and properties of recombinant homocysteine, a, g-lyase.  Protein Expression and Purification 14, 267-274, 1998.

8.       Tan et al.  Total-homocysteine enzymatic assay.  Clin. Chem. 46, 1686-1688, 2000.